Publications

Link to author pubmed.

 

High  resolution  time-course  mapping  of  early  transcriptomic,  molecular  and  cellular phenotypes   in   Huntington’s   disease   CAG   knock-in   mice   across   multiple   genetic backgrounds

Human Molecular Genetics  2017

Seth A. Ament*, Jocelynn R. Pearl*, Andrea Grindeland*, Jason St. Claire, John C.  Earls, Marina  Kovalenko ,  Tammy  Gillis,  Jayalakshmi  Mysore, James  F. Gusella, Jong-Min Lee, Seung Kwak, David Howland, Min Young  Lee, David Baxter, Kelsey Scherler, Kai Wang, Donald Geman, Jeffrey B. Carroll, Marcy E. MacDonald, George Carlson, Vanessa C. Wheeler, Nathan D. Price, and Leroy E. Hood

* contributed equally to this work 

Genome-scale transcriptional regulatory network models for the mouse and human striatum predict roles for SMAD3 and other transcription factors in Huntington's disease.  

bioRxiv preprint

Seth A Ament*, Jocelynn R Pearl*, Robert Bragg, Peter J Skene, Sydney Coffey, Dani E Bergey, Christopher Plaisier, Vanessa Wheeler, Marcy MacDonald, Nitin S Baliga, Jim Rosinski, Leroy E Hood, Jeffrey B Carroll, Nathan D Price

* contributed equally

Targeted gene addition in human CD34+ hematopoietic cells for correction of X-linked chronic granulomatous disease.  

NATURE BIOTECHNOLOGY 2016

De Ravin SS, Reik A, Liu PQ, Li L, Wu X, Su L, Raley C, Theobald N, Choi U, Song AH, Chan A, Pearl JR, Paschon DE, Lee J, Newcombe H, Koontz S, Sweeney C, Shivak DA, Zarember KA, Peshwa MV, Gregory PD, Fyodor D Urnov & Harry L Malech. 

Translating Dosage Compensation to Trisomy 21.  

NATURE 2013

Jiang, Jing, Cost, Kolpa, Cotton, Chiang, Carone D, Carone B, Shivak, Guschin, Pearl, Rebar, Byron, Gregory, Brown, Urnov, Hall, and Jeanne B. Lawrence. 

Activation Domains for Controlling Plant Gene Expression Using Designed Transcription Factors. 

PLANT BIOTECHNOLOGY JOURNAL 2013

 Li, Blue, Zeitler, Strange, Pearl, Huizinga, Evans, Gregory, Urnov and Joseph F. Petolino.

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases. 

NATURE METHODS 2012

Straimer, Lee, Andrew H Lee, Zeitler, Williams, Pearl, Zhang, Rebar, Gregory, Llinás, Urnov and David A Fidock.